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In pathophysiological states, including increased insulin resistance, the hybrid receptor number is changed significantly, thus potentially abrogating the chance for IGF-1 to alter glucose metabolism [129, 132, 133]
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While these findings have generated significant interest, human studies remain limited, making it difficult to draw definitive conclusions about its clinical benefits
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Moreover, alcoholics may experience reduced intestinal absorption of vitamin B 12 (2), and individuals with acquired immunodeficiency syndrome (AIDS) appear to be at increased risk of deficiency, possibly related to a failure of the IF-B 12 receptor to take up the IF-B 12 complex (3)
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